In forensic autopsy cases, transient brain hypoxia can be induced by cardiac arrest, hypovolemic shock, and other conditions with severe circulatory failure. Although cortical laminar necrosis in watershed areas between territories of the major cerebral arteries is occasionally seen, cases with global hypoxic damage to the brain is rare, because patients with irreversible severe brain damage rarely survive for more than a few days. In this report we describe autopsy results for an injury victim who survived unconscious for approximately 4 weeks after admission. Macroscopic thinning of the gray matter and uniformly cheesecake-like cloudy changes in white matter were observed. Microscopically, cortical laminar necrosis was observed in all lobes of the cerebrum, and massive gliosis was diffused throughout the white matter. We speculate that traumatic brain damage, continuous hypoxemia, and many other factors induced these characteristic pathological changes during the long time interval from brain damage to death.
| Symptom | Subdomain | Domain |
|---|---|---|
| loss of consciousness | Consciousness | Arousal and Regulatory Systems |
Validated by: No users have validated this case report yet.
Rejected by: No users have rejected this case report yet.
Please log in to validate this case report.
No subjects have been added to this case report yet.
Please log in to add a subject.
No notes have been submitted for this case report yet.